MRTX1133 is a potent and selective KRAS G12D inhibitor. MRTX1133 targets the KRAS G12D protein in both active and inactive states. In preclinical studies, MRTX1133 exhibited a long half-life, an ability to bind the KRAS G12D protein in both active and inactive states, and selective inhibition of KRAS G12D mutant cancer cells. In G12D mutant tumor models, MRTX1133 showed dose-dependent selective inhibition of the KRAS pathway and tumor regression.

 

Brand: BCM

 

Solubility: Soluble in DMSO.

 

InChi Key: SCLLZBIBSFTLIN-IFMUVJFISA-N

 

Attribute
[Chem Name]	4-(4-(3,8-Diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol
[Synonym]	MRTX1133; MRTX-1133; MRTX 1133
[CAS No.]	2621928-55-8
[MDL No.]	MFCD34567005
[Formula]	C33H31F3N6O2
[Molecular]	600.63
[Form]	Solid powder

Goods Tag