Carfilzomib is an irreversible inhibitor of proteasome with IC50 values < 5 nM in ANBL-6 and RPMI 8226 cells.

 

Brand: BCM

 

Target: IC50: 5 nM (Proteasome)

 

Signaling Pathways: Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination

 

Boiling Point: 975.6±65.0 °C at 760 mmHg

 

Flashing Point: 543.8±34.3 °C 

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CC(C)C[C@@H](C(=O)[C@]1(CO1)C)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC3=CC=CC=C3)NC(=O)CN4CCOCC4  

 

InChIKey: BLMPQMFVWMYDKT-NZTKNTHTSA-N  

 

InChI: InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1

 

Attribute
[Chem Name]	(S)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide
[Synonym]	PR-171; Carfilzomib
[CAS No.]	868540-17-4
[EINECS]	692-054-2
[MDL No.]	MFCD11040997
[Formula]	C40H57N5O7
[Molecular]	719.92
[Form]	White solid powder
[Storage]	-20°C

Goods Tag