JNJ-10198409 is a relatively selective, orally active and ATP-competitive inhibitor of platelet-derived growth factor receptor (PDGF-RTK) with an IC50 of 2 nM, It is also a dual-mechanism, anti-angiogenic and anti-tumor cell proliferative agent with good inhibitory activity against PDGFRβ kinase and PDGFRα kinase with IC50 of 4.2 and 45 nM, respectively.

 

Brand: BCM

 

pKa: 14.01±0.20(Predicted)

 

Melting Point: 171-173.5 °C

 

Boiling Point: 528.8±50.0 °C at 760 mmHg

 

Flashing Point: 273.6±30.1 °C

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Attribute
[Chem Name]	N-(3-Fluorophenyl)-6,7-dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
[Synonym]	JNJ-10198409
[CAS No.]	627518-40-5
[MDL No.]	MFCD11045292
[Formula]	C18H16FN3O2
[Molecular]	325.34
[Form]	Off-white solid
[Storage]	−20°C

Goods Tag