Masitinib mesylate (AB-1010 mesylate) is a potent, bioorally available, and selective c-Kit inhibitor (IC50 at 200 nM for human recombinant c-Kit). PDGFRα/β (IC50 at 540/800 nM), Lyn (IC50 at 510 nM for LynB), and to a lesser extent FGFR3 and FAK were also inhibited.

 

Brand: BCM

 

Target: IC50: 200 nM (Kit), 540 nM (PDGFRα), 800 nM (PDGFRβ)

 

Solubility: Soluble in DMSO.

 

InChi Key: TXCWBWKVIZGWEQ-UHFFFAOYSA-N

 

Attribute
[Chem Name]	N-(4-Methyl-3-((4-(pyridin-3-yl)thiazol-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide methanesulfonate
[Synonym]	Masitinib Mesylate；AB-1010 mesylate
[CAS No.]	1048007-93-7
[MDL No.]	MFCD12546334
[Formula]	C29H34N6O4S2
[Molecular]	594.74806
[Form]	Powder
[Storage]	Inert atmosphere. Store in freezer, under -20°C

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