Doravirine (MK-1439) is an HIV-1 single nucleotide reverse transcriptase inhibitor with IC50 of 12 nM, 9.7 nM, and 9.7 nM for wild-type reverse transcriptase and reverse transcriptase carrying mutations in K103N and Y181C, respectively. It is very specific and has very few off-target effects.

 

Brand: BCM

 

Melting Point: >278°C (dec.)

 

In Vitro: The IC50 of MK-1439 for DNA polymerase α, ß and γ in cells was greater than 100 μM. In the screening of protein targets (including enzymes, transporters, ion channels and receptors) in 110, the IC50 value of MK-1439 for most targets was greater than 10 μM, except for 5-HT2β, which was 2.5 μM for MK-1429 in the ligand binding assay. However, no 5-HT2ß activity was detected in the accumulation of inositol-1-phosphate in cells. In activated CD4+ T cells, peripheral blood monocytes, and macrophage proliferative transformation cell lines, MK-1439 showed no cytotoxicity at concentrations up to 100 μM.

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

Shelf Life: >2 years if stored properly

 

InChi Key: ZIAOVIPSKUPPQW-UHFFFAOYSA-N

 

Attribute
[Chem Name]	3-Chloro-5-((1-((4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile
[Synonym]	Doravirine; MK-1439; MK1439
[CAS No.]	1338225-97-0
[MDL No.]	MFCD22417167
[Formula]	C17H11ClF3N5O3
[Molecular]	425.75
[Form]	White to Off-White Solid
[Storage]	Sealed in dry. -20°C Freezer

Goods Tag