Tolvaptan (OPC-41061) is a selective, competitive arginine vasopressin receptor 2 antagonist that inhibits AVP-induced platelet aggregation with an IC50 of 1.28µM.

 

Brand: BCM

 

Chloride: ≤ 0.01%

 

Heavy metals: ＜10ppm

 

Ferric salt: ≤ 0.001%

 

Melting Point: 219-222°C

 

pKa: 13.00±0.70(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C  

 

InChIKey: GYHCTFXIZSNGJT-UHFFFAOYSA-N  

 

InChI: InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)

 

Attribute
[Chem Name]	N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
[Synonym]	Tolvaptan; OPC-41061
[CAS No.]	150683-30-0
[EINECS]	691-537-5
[MDL No.]	MFCD09838782
[Formula]	C26H25ClN2O3
[Molecular]	448.94
[Form]	White to tan solid powder
[Storage]	Sealed in dry. 2-8°C

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