Dabrafenib Mesylate (GSK2118436) is the mesylate salt form of dabrafenib, an orally bioavailable inhibitor of B-raf (BRAF) protein with IC50s of 0.7 nM, 5.2 nM and 6.3 nM for B-Raf (V600E), B-Raf (WT) and C-Raf, respectively.

 

Brand: BCM

 

Signaling Pathways: MAPK

 

Melting Point: >234°C (dec.)

 

Stability: Hygroscopic

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F.CS(=O)(=O)O  

 

InChIKey: YKGMKSIHIVVYKY-UHFFFAOYSA-N  

 

InChI: InChI=1S/C23H20F3N5O2S2.CH4O3S/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25;1-5(2,3)4/h4-11,31H,1-3H3,(H2,27,28,29);1H3,(H,2,3,4)

 

Attribute
[Chem Name]	N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide methanesulfonate
[Synonym]	Dabrafenib mesylate； GSK-2118436B
[CAS No.]	1195768-06-9
[EINECS]	689-167-4
[MDL No.]	MFCD20922872
[Formula]	C24H24F3N5O5S3
[Molecular]	615.66
[Form]	White to Off-White Solid
[Storage]	Keep in dark place. Inert atmosphere. Room temperature

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