CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells from MPP+ induced cytotoxicity by activating the Keap1-Nrf2 cascade.

 

Brand: BCM

 

Boiling Point: 592.4±50.0 °C(Predicted)

 

pKa: 6.28±0.40(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CC(C)CN[C@H]1CS(=O)(=O)C[C@@H]1S(=O)(=O)C2=CC=C(C=C2)Cl  

 

InChIKey: NFEQFEDSWINARK-KBPBESRZSA-N  

 

InChI: InChI=1S/C14H20ClNO4S2/c1-10(2)7-16-13-8-21(17,18)9-14(13)22(19,20)12-5-3-11(15)4-6-12/h3-6,10,13-14,16H,7-9H2,1-2H3/t13-,14-/m0/s1

 

Attribute
[Chem Name]	3-Thiophenamine, 4-[(4-chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-, 1,1-dioxide, (3R,4S)-rel-
[Synonym]	CBR-470-1
[CAS No.]	2416095-06-0
[Formula]	C14H20ClNO4S2
[Molecular]	365.89
[Form]	White to beige solid powder

Goods Tag