Cher-090 is a potent and tightly binding deacetylase inhibitor of LpxC. It can bind to E. coli LpxC with 4.0 nM Ki.

 

Brand: BCM

 

pKa: 9.11±0.40(Predicted)

 

Signaling Pathways: Microbiology/Virology

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: C[C@H]([C@@H](C(=O)NO)NC(=O)C1=CC=C(C=C1)C#CC2=CC=C(C=C2)CN3CCOCC3)O  

 

InChIKey: FQYBTYFKOHPWQT-VGSWGCGISA-N  

 

InChI: InChI=1S/C24H27N3O5/c1-17(28)22(24(30)26-31)25-23(29)21-10-8-19(9-11-21)3-2-18-4-6-20(7-5-18)16-27-12-14-32-15-13-27/h4-11,17,22,28,31H,12-16H2,1H3,(H,25,29)(H,26,30)/t17-,22+/m1/s1

 

Attribute
[Chem Name]	N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]benzamide
[Synonym]	CHIR-090
[CAS No.]	728865-23-4
[MDL No.]	MFCD22665727
[Formula]	C24H27N3O5
[Molecular]	437.49
[Form]	Solid
[Storage]	Inert atmosphere,2-8°C

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