iKIX1 is an Pdr1-dependent gene activation. It re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in animal models for disseminated and urinary tract C. glabrata infection.

 

Brand: BCM

 

Target: Interaction between CgGal11A and CgPdr1:18 μM (Ki), interaction between CgGal11A and CgPdr1:190.2 μM (IC50)

 

Signaling Pathways: Microbiology/Virology

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

Isomeric SMILES: C1=CC(=C(C=C1NC(=S)NNC(=O)CC#N)Cl)Cl  

 

InChIKey: XKQJVBSDCOCZFV-UHFFFAOYSA-N  

 

InChI: InChI=1S/C10H8Cl2N4OS/c11-7-2-1-6(5-8(7)12)14-10(18)16-15-9(17)3-4-13/h1-2,5H,3H2,(H,15,17)(H2,14,16,18)  

 

Attribute
[Chem Name]	1-[(2-cyanoacetyl)amino]-3-(3,4-dichlorophenyl)thiourea
[Synonym]	iKIX1
[CAS No.]	656222-54-7
[MDL No.]	MFCD00119122
[Formula]	C10H8Cl2N4OS
[Molecular]	303.17
[Form]	A crystalline solid
[Storage]	Inert atmosphere. Room Temperature

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