O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-Desmethyl gefitinib depends on CYP2D6 activity. In subcellular trials, O-Desmethyl gefitinib inhibited EGFR at IC50 at 36 nM.

 

Brand: BCM

 

Melting Point: 117-120°C

 

Stability: Hygroscopic

 

Signaling Pathways: Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors

 

Target Activity: EGFR:36 nM (IC50)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: C1COCCN1CCCOC2=C(C=C3C(=C2)C(=NC=N3)NC4=CC(=C(C=C4)F)Cl)O  

 

InChIKey: IFMMYZUUCFPEHR-UHFFFAOYSA-N  

 

InChI: InChI=1S/C21H22ClFN4O3/c22-16-10-14(2-3-17(16)23)26-21-15-11-20(19(28)12-18(15)24-13-25-21)30-7-1-4-27-5-8-29-9-6-27/h2-3,10-13,28H,1,4-9H2,(H,24,25,26) 

 

Attribute
[Chem Name]	4-(3-chloro-4-fluoroanilino)-6-(3-morpholin-4-ylpropoxy)quinazolin-7-ol
[CAS No.]	847949-49-9
[MDL No.]	MFCD09952182
[Formula]	C21H22ClFN4O3
[Molecular]	432.88
[Form]	Yellow Solid
[Storage]	Keep in dark place. Inert atmosphere, 2-8°C

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