UZH2 is a potent and selective METTL3 inhibitor with an IC50 value of 5 nM in the TR-FRET assay.

 

Brand: BCM

 

Solublility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CC1(CCN(CC1)CC2=CC(=C(C=C2F)N3CC(=O)NC4(C3)CCN(CC4)C5=NC=NC(=C5)NC)F)C  

 

InChIKey: GYWOVBUGFWWSJR-UHFFFAOYSA-N  

 

InChI: InChI=1S/C27H37F2N7O/c1-26(2)4-8-34(9-5-26)15-19-12-21(29)22(13-20(19)28)36-16-25(37)33-27(17-36)6-10-35(11-7-27)24-14-23(30-3)31-18-32-24/h12-14,18H,4-11,15-17H2,1-3H3,(H,33,37)(H,30,31,32) 

 

Attribute
[Chem Name]	4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one
[Synonym]	UZH2
[CAS No.]	2756566-45-5
[Formula]	C27H37F2N7O
[Molecular]	513.64
[Form]	White to off-white solid
[Storage]	Powder: -20°C for 3 years. In solvent: -80°C for 2 years

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