Epacadostat (INCB024360) is a potent and selective indoleamine 2, 3-dioxygenase (IDO1) inhibitor with an IC50 of 10 nM. It is more selective to IDO1 than other related enzymes such as IDO2 or TDO.

 

Brand: BCM

 

Melting Point: 159 - 161°C

 

Boiling Point: 700.9±70.0 °C(Predicted)

 

pKa: 7.65±0.69(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol (warmed with 50ºC water bath). Insoluble in Water.

 

Isomeric SMILES: C1=CC(=C(C=C1N=C(C2=NON=C2NCCNS(=O)(=O)N)NO)Br)F  

 

InChIKey: FBKMWOJEPMPVTQ-UHFFFAOYSA-N  

 

InChI: InChI=1S/C11H13BrFN7O4S/c12-7-5-6(1-2-8(7)13)17-11(18-21)9-10(20-24-19-9)15-3-4-16-25(14,22)23/h1-2,5,16,21H,3-4H2,(H,15,20)(H,17,18)(H2,14,22,23)  

 

Attribute
[Chem Name]	N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboximidamide
[Synonym]	Epacadostat; INCB024360
[CAS No.]	1204669-58-8
[EINECS]	815-121-1
[MDL No.]	MFCD29075639
[Formula]	C11H13BrFN7O4S
[Molecular]	438.23
[Form]	White solid
[Storage]	Sealed in dry, 2-8°C

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