MBM-55S is a potent inhibitor of NIMA-related kinase 2 (Nek2) with an IC50 of 1 nM, which is 20 times or more selective than other kinases. In addition to RSK1 (IC50=5.4 nM) and DYRK1a (IC50=6.5 nM). MBM-55S inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. It has antitumor activity and no obvious toxicity to mice.

 

Brand: BCM

 

Target: Aurora A:5300 nM , Chk1:57 nM , DYRK1A:6.5 nM , CDK4:441nM , Abl:20 nM , CDK2:370 nM , Nek2:1 nM , GSK-3β:91 nM , Akt1:608 nM , RSK1:5.4 nM

 

Signaling Pathways: Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling; Angiogenesis; MAPK; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling; Stem Cells

 

Isomeric SMILES: CN(C)CCN1C=C(C=N1)C2=CC3=NC=C(N3C=C2)C4=CC(=C(C=C4)C(=O)N)OCC5=CC(=CC=C5)F.C(CC(=O)O)C(=O)O.C(CC(=O)O)C(=O)O  

 

InChIKey: AXYNDQVILOZBNY-UHFFFAOYSA-N  

 

InChI: InChI=1S/C28H27FN6O2.2C4H6O4/c1-33(2)10-11-34-17-22(15-32-34)20-8-9-35-25(16-31-27(35)14-20)21-6-7-24(28(30)36)26(13-21)37-18-19-4-3-5-23(29)12-19;2*5-3(6)1-2-4(7)8/h3-9,12-17H,10-11,18H2,1-2H3,(H2,30,36);2*1-2H2,(H,5,6)(H,7,8) 

 

Attribute
[Chem Name]	butanedioic acid;4-[7-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-[(3-fluorophenyl)methoxy]benzamide
[Synonym]	MBM-55S
[CAS No.]	2083624-07-9
[MDL No.]	MFCD34470269
[Formula]	C32H33FN6O6
[Molecular]	616.65
[Storage]	Powder: -20°C for 3 years. In solvent: -80°C for 2 years

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