ALLO-2 is an effective antagonist of wild-type mouse Smo and drug-resistant D473H mutant human Smo. It can inhibit Gli responsive element-Luciferase (Gli Luc) activity in TM3-Gli Luc cells with IC50 of 6 nM.

 

Brand: BCM

 

Target: IC50: Smo

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: C1=CC(=CC=C1C2=NC(=NC=C2)NC3=CC4=C(C=C3)NN=C4)OC(F)(F)F  

 

InChIKey: QTYGEBIJNWMVCW-UHFFFAOYSA-N  

 

InChI: InChI=1S/C18H12F3N5O/c19-18(20,21)27-14-4-1-11(2-5-14)15-7-8-22-17(25-15)24-13-3-6-16-12(9-13)10-23-26-16/h1-10H,(H,23,26)(H,22,24,25)

 

Attribute
[Chem Name]	N-[4-[4-(trifluoromethoxy)phenyl]pyrimidin-2-yl]-1H-indazol-5-amine
[Synonym]	ALLO-2
[CAS No.]	1357350-60-7
[MDL No.]	MFCD28160326
[Formula]	C18H12F3N5O
[Molecular]	371.32
[Form]	Solid
[Storage]	Keep in dark place. Sealed in dry. Room Temperature

Goods Tag