GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3, with an IC50 of 2 nM/13 nM/9 nM in cell-free studies, and is also sensitive to the AGC kinase family :PKA, PrkX, and PKC isoenzymes. GSK690693 also effectively inhibited AMPK and DAPK3 of the CAMK family, with corresponding IC50 values of 50 nM and 81 nM, respectively. GSK690693 can affect the activity of Unc-51-like autophagy activating kinase 1 (ULK1) and effectively inhibit the activation of STING-dependent IRF3. Phase 1.

 

Brand: BCM

 

Target: PKC; Akt; Serine Protease; Autophagy; AMPK

 

Signaling Pathways: Cytoskeletal Signaling; Autophagy; Proteases/Proteasome; PI3K/Akt/mTOR signaling; Chromatin/Epigenetic

 

Boiling Point: 683.8±65.0 °C at 760 mmHg

 

Flashing Point: 367.3±34.3 °C

 

pKa: 13.11±0.29(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS06

 

Isomeric SMILES: CCN1C2=C(C(=NC=C2OC[C@H]3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N  

 

InChIKey: KGPGFQWBCSZGEL-ZDUSSCGKSA-N  

 

InChI: InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1

 

Attribute
[Chem Name]	4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[[(3S)-piperidin-3-yl]methoxy]imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol
[Synonym]	GSK690693; GSK-690693
[CAS No.]	937174-76-0
[MDL No.]	MFCD14105605
[Formula]	C21H27N7O3
[Molecular]	425.48
[Form]	White to beige powder
[Storage]	Keep in dark place. Inert atmosphere, 2-8°C

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