1-naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of Src family kinases. v-Src, c-Fyn, c-Abl, CDK2 and CAMKII were inhibited with IC50 of 1.0, 0.6, 0.6, 18 and 22 μM, respectively.

 

Brand: BCM

 

Target: c-Fyn:0.6 μM , v-Src:1.0 μM , CDK2:18 μM , CaMK II:22 μM , c-Abl:0.6 μM

 

Signaling Pathways: Angiogenesis; Tyrosine Kinase/Adaptors

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CC(C)(C)N1C2=NC=NC(=C2C(=N1)C3=CC=CC4=CC=CC=C43)N.Cl  

 

InChIKey: UKLRSYUALPIALU-UHFFFAOYSA-N  

 

InChI: InChI=1S/C19H19N5.ClH/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14;/h4-11H,1-3H3,(H2,20,21,22);1H

 

Attribute
[Chem Name]	1-tert-butyl-3-naphthalen-1-ylpyrazolo[3,4-d]pyrimidin-4-amine;hydrochloride
[Synonym]	1-NA-PP 1 hydrochloride; 1-Naphthyl PP1 hydrochloride
[CAS No.]	956025-47-1
[MDL No.]	MFCD28142637
[Formula]	C19H20ClN5
[Molecular]	353.8486
[Storage]	Store at -20°C

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