Imatinib (STI571, CGP057148B) Mesylate, an oral biopotent Imatinib mesylate, is a multi-target inhibitor that acts on v-Abl, c-Kit, and PDGFR with an IC50 of 0.6 μM, respectively, in cell-free and cellular trials. 0.1 μM and 0.1 μM. Imatinib Mesylate (STI571) can induce autophagy.

 

Brand: BCM

 

Melting Point: 214-224°C

 

Boiling Point: 133-134 °C(lit.)

 

Flashing Point: 64°F

 

Target: Autophagy; Bcr-Abl; PDGFR; c-Kit

 

Signaling Pathways: Cytoskeletal Signaling; Tyrosine Kinase/Adaptors; Autophagy; Angiogenesis

 

Solubility: Soluble in DMSO; soluble in Water. Insoluble in Ethanol.

 

GHS: GHS07, GHS08

 

Isomeric SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O  

 

InChIKey: YLMAHDNUQAMNNX-UHFFFAOYSA-N  

 

InChI: InChI=1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4) 

 

Attribute
[Chem Name]	methanesulfonic acid;4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
[Synonym]	Imatinib (STI571, CGP057148B) Mesylate; CGP-57148B; STI571
[CAS No.]	220127-57-1
[EINECS]	606-892-3
[MDL No.]	MFCD04307699
[Formula]	C30H35N7O4S
[Molecular]	589.71
[Form]	White to beige solid
[Storage]	Sealed in dry. Room Temperature

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