MS-873 is a specific allosteric inhibitor of p97 with IC50=30nM, and is more selective to VCP/p97 than other AAA Atpases, Hsp90, and other detected kinases.

 

Brand: BCM

 

Target: p97

 

Signaling Pathways: Ubiquitination

 

Melting Point: >220°C (dec.)

 

Boiling Point: 769.3±70.0 °C(Predicted)

 

pKa: 2.48±0.12(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: CC1=C(C=CC(=C1)OCC2=NN=C(N2C3=CN=CC=C3)SC4CCCC4)C5=CC=C(C=C5)S(=O)(=O)C  

 

InChIKey: UJGTUKMAJVCBIS-UHFFFAOYSA-N  

 

InChI: InChI=1S/C27H28N4O3S2/c1-19-16-22(11-14-25(19)20-9-12-24(13-10-20)36(2,32)33)34-18-26-29-30-27(35-23-7-3-4-8-23)31(26)21-6-5-15-28-17-21/h5-6,9-17,23H,3-4,7-8,18H2,1-2H3

 

Attribute
[Chem Name]	3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine
[Synonym]	NMS-873; NMS873
[CAS No.]	1418013-75-8
[EINECS]	200-256-5
[MDL No.]	MFCD28009371
[Formula]	C27H28N4O3S2
[Molecular]	520.67
[Form]	White to beige powder
[Storage]	Sealed in dry. Room Temperature

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