Nirogacestat (PF-03084014, PF-3084014) is a selective gamma-secretase inhibitor with an IC50 of 6.2 nM in cell-free trials. Nirogacestat (PF-03084014, PF-3084014) can induce apoptosis. Phase 2.

 

Brand: BCM

 

Target: Gamma-secretase; Apoptosis

 

Signaling Pathways: Apoptosis; Neuroscience; Proteases/Proteasome; Stem Cells

 

Solubility: Soluble in DMSO (warmed with 50ºC water bath); soluble in Ethanol (warmed with 50ºC water bath). Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: CCC[C@@H](C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C)N[C@H]2CCC3=C(C2)C(=CC(=C3)F)F  

 

InChIKey: VFCRKLWBYMDAED-REWPJTCUSA-N  

 

InChI: InChI=1S/C27H41F2N5O/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4/h11-12,14,17,20,23,30,32H,7-10,13,15-16H2,1-6H3,(H,33,35)/t20-,23-/m0/s1 

 

Attribute
[Chem Name]	(2S)-2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methylpropan-2-yl]imidazol-4-yl]pentanamide
[Synonym]	Nirogacestat；PF-03084014； PF3084014
[CAS No.]	1290543-63-3
[MDL No.]	MFCD19980705
[Formula]	C27H41F2N5O
[Molecular]	489.64
[Storage]	Keep in dark place. Inert atmosphere. Store in freezer, under -20°C
[Risk Codes]	H315-H319-H335
[Form]	White to beige solid powder

Goods Tag