VH298 is a potent inhibitor of VHL (Von Hippel-Lindau, the E3 ligase) that stabilizes HIF-α. VH298 blocks the VHL:HIF-α interaction with Kd values of 90 nM in isothermal titration thermal analysis (ITC) and 80 nM in competitive fluorescence polarization assay. The VH-298 can be used in PROTAC technology.

 

Brand: BCM

 

Boiling Point: 860.8±65.0 °C(Predicted)

 

Target: Ligand for E3 Ligase; Others; HIF

 

Signaling Pathways: Angiogenesis; Chromatin/Epigenetic; Others; PROTAC

 

pKa: 12.28±0.20(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)C4(CC4)C#N)O  

 

InChIKey: NDVQUNZCNAMROD-RZUBCFFCSA-N  

 

InChI: InChI=1S/C27H33N5O4S/c1-16-21(37-15-30-16)18-7-5-17(6-8-18)12-29-23(34)20-11-19(33)13-32(20)24(35)22(26(2,3)4)31-25(36)27(14-28)9-10-27/h5-8,15,19-20,22,33H,9-13H2,1-4H3,(H,29,34)(H,31,36)/t19-,20+,22-/m1/s1

 

Attribute
[Chem Name]	(2S,4R)-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
[Synonym]	VH298; VH-298; VH 298
[CAS No.]	2097381-85-4
[MDL No.]	MFCD30742947
[Formula]	C27H33N5O4S
[Molecular]	523.65
[Form]	A crystalline solid
[Storage]	Sealed in dry, 2-8°C

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