JNK inhibitor IX (TCS JNK 5a) is a highly selective JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively.

 

Brand: BCM

 

Target: Apoptosis; JNK

 

Signaling Pathways: Apoptosis; MAPK

 

In Vitro: In human skin fibroblasts, JNK inhibitor IX significantly reduces caspase-3 activity by inhibiting JNK inhibitor IX-mediated JNK inhibition by preventing complete dephosphorylation of c-ABL on serine residues. Apoptotic death was significantly increased after imatinib mesylate (IM) treatment.

 

Boiling Point: 486.8±45.0 °C at 760 mmHg

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: C1CCC2=C(C1)C(=C(S2)NC(=O)C3=CC=CC4=CC=CC=C43)C#N  

 

InChIKey: WQGDQGAFSDMBLA-UHFFFAOYSA-N  

 

InChI: InChI=1S/C20H16N2OS/c21-12-17-15-9-3-4-11-18(15)24-20(17)22-19(23)16-10-5-7-13-6-1-2-8-14(13)16/h1-2,5-8,10H,3-4,9,11H2,(H,22,23) 

 

Attribute
[Chem Name]	N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide
[CAS No.]	312917-14-9
[MDL No.]	MFCD01005305
[Formula]	C20H16N2OS
[Molecular]	332.42
[Form]	Off-white to tan solid
[Storage]	Keep in dark place. Sealed in dry. Room Temperature
[Synonym]	JNK inhibitor IX; TCS JNK 5a; SC-202671

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