Ritlecitinib (PF-06651600) is a JAK3-selective inhibitor with an IC50 of 33.1 nM. No activity on JAK1, JAK2 and TYK2 (IC50 > 10 000 nM).

 

Brand: BCM

 

Target: JAK

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

pKa: 13.03±0.50(Predicted)

 

GHS: GHS07

 

Isomeric SMILES: C[C@H]1CC[C@H](CN1C(=O)C=C)NC2=NC=NC3=C2C=CN3  

 

InChIKey: CBRJPFGIXUFMTM-WDEREUQCSA-N  

 

InChI: InChI=1S/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/m0/s1

 

Attribute
[Chem Name]	1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]prop-2-en-1-one
[Synonym]	Ritlecitinib; PF-06651600
[CAS No.]	1792180-81-4
[MDL No.]	MFCD31697544
[Formula]	C15H19N5O
[Molecular]	285.34
[Form]	White to beige powder
[Storage]	Keep in dark place. Sealed in dry, 2-8°C

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