Evixapodlin is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.

 

Brand: BCM

 

Target: Human PD-1/PD-L1 protein/protein interaction:0.213 nM (IC50)

 

In Vitro: Evixapodlin exhibits an ability to increase the production of IFN-γ and Granzyme B in both CD8+ and CD4+ T cells in individuals with chronic hepatitis B (CHB). Additionally, Evixapodlin enhances the frequency of Granzyme B-positive cells among HBV-specific CD8+ and CD4+ T cells.

 

Boiling Point: 817.1±65.0 °C(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

pKa: 15.81±0.40(Predicted)

 

Isomeric SMILES: COC1=NC(=CN=C1CNC[C@@H]2CCC(=O)N2)C3=CC=CC(=C3Cl)C4=C(C(=CC=C4)C5=CN=C(C(=N5)OC)CNC[C@@H]6CCC(=O)N6)Cl  

 

InChIKey: OIIOPWHTJZYKIL-PMACEKPBSA-N  

 

InChI: InChI=1S/C34H36Cl2N8O4/c1-47-33-27(15-37-13-19-9-11-29(45)41-19)39-17-25(43-33)23-7-3-5-21(31(23)35)22-6-4-8-24(32(22)36)26-18-40-28(34(44-26)48-2)16-38-14-20-10-12-30(46)42-20/h3-8,17-20,37-38H,9-16H2,1-2H3,(H,41,45)(H,42,46)/t19-,20-/m0/s1

 

Attribute
[Chem Name]	(5S)-5-[[[5-[2-chloro-3-[2-chloro-3-[6-methoxy-5-[[[(2S)-5-oxopyrrolidin-2-yl]methylamino]methyl]pyrazin-2-yl]phenyl]phenyl]-3-methoxypyrazin-2-yl]methylamino]methyl]pyrrolidin-2-one
[Synonym]	Evixapodlin; GS-4224; PD-1/PD-L1-IN 7
[CAS No.]	2374856-75-2
[Formula]	C34H36Cl2N8O4
[Molecular]	691.61
[Form]	Powder
[Storage]	Store at -20°C

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