Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment.

 

Brand: BCM

 

Target: Apoptosis; PTEN; Antioxidant; PI3K; Autophagy

 

Signaling Pathways: Apoptosis; Autophagy; oxidation-reduction; PI3K/Akt/mTOR signaling

 

Boiling Point: 957.5±65.0 °C at 760 mmHg

 

Flashing Point: 318.1±27.8 °C

 

Vapour Pressure: 0.0±0.3 mmHg at 25°C

 

Solubility: Soluble in DMSO. 

 

Isomeric SMILES: C1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)O)O)O)O)O  

 

InChIKey: HAYLVXFWJCKKDW-IJTBWITGSA-N  

 

InChI: InChI=1S/C27H30O15/c28-8-15-19(31)22(34)24(36)26(41-15)38-9-16-20(32)23(35)25(37)27(42-16)40-14-7-13-17(21(33)18(14)30)11(29)6-12(39-13)10-4-2-1-3-5-10/h1-7,15-16,19-20,22-28,30-37H,8-9H2/t15-,16-,19-,20-,22+,23+,24-,25-,26-,27-/m1/s1

 

Attribute
[Chem Name]	5,6-dihydroxy-2-phenyl-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
[Synonym]	Oroxin B; Hypocretin-2; Baicalin-7-diglucoside
[CAS No.]	114482-86-9
[MDL No.]	MFCD22125002
[Formula]	C27H30O15
[Molecular]	594.52
[Form]	Yellowish Powder
[Storage]	Sealed in dry, 2-8°C

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