BI-2865 is a non-covalent pan-KRAs inhibitor. BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD of 6.9, 4.5, 32, 26, and 4.3 nM, respectively. BI-2865 inhibits proliferation of BaF3 cells expressing KRAS G12C, G12D, or G12V mutants (mean IC50: approximately 140 nM).

 

Brand: BCM

 

Target: Ras

 

Signaling Pathways: GPCR/G Protein

 

Boiling Point: 708.7±70.0 °C(Predicted)

 

pKa: 9.35±0.40(Predicted)

 

Isomeric SMILES: N#CC1=C(N)SC2=C1[C@@](C)(C3=NC(C4=NC(O[C@@H](C)[C@@H]5CCCN5C)=CC=N4)=NO3)CCC2

 

InChIKey: MIUFORKWYHBPRW-HMFCALDFSA-N

 

InChI: InChI=1S/C23H27N7O2S/c1-13(15-6-5-11-30(15)3)31-17-8-10-26-20(27-17)21-28-22(32-29-21)23(2)9-4-7-16-18(23)14(12-24)19(25)33-16/h8,10,13,15H,4-7,9,11,25H2,1-3H3/t13-,15-,23-/m0/s1

 

Attribute
[Chem Name]	(S)-2-amino-4-methyl-4-(3-(4-((S)-1-((S)-1-methylpyrrolidin-2-yl)ethoxy)pyrimidin-2-yl)-1,2,4-oxadiazol-5-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile
[Synonym]	BI-2865; BI 2865; BI2865
[CAS No.]	2937327-93-8
[Formula]	C23H27N7O2S
[Molecular]	465.57

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