SBP-7455 is a bi-specific ULK1/2 autophagy inhibitor with IC50 of 13 nM and 476 nM for ULK1 and ULK2 in the ADP-Glo assay.

 

Brand: BCM

 

Target: Autophagy:0.3 μM

 

Signaling Pathways: Autophagy

 

Boiling Point: 490.2±55.0 °C(Predicted)

 

pKa: 3.29±0.10(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: COC1=C(C=C(C=C1)NC2=NC=C(C(=N2)NC3CC3)C(F)(F)F)OC  

 

InChIKey: BQROJYIEHOOQBY-UHFFFAOYSA-N  

 

InChI: InChI=1S/C16H17F3N4O2/c1-24-12-6-5-10(7-13(12)25-2)22-15-20-8-11(16(17,18)19)14(23-15)21-9-3-4-9/h5-9H,3-4H2,1-2H3,(H2,20,21,22,23)

 

Attribute
[Chem Name]	4-N-cyclopropyl-2-N-(3,4-dimethoxyphenyl)-5-(trifluoromethyl)pyrimidine-2,4-diamine
[Synonym]	SBP-7455; SBP 7455; SBP7455
[CAS No.]	1884222-74-5
[MDL No.]	MFCD32899898
[Formula]	C16H17F3N4O2
[Molecular]	354.33
[Form]	A crystalline solid
[Storage]	Inert atmosphere. Room Temperature

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