MRT68921 hydrochloride is a potent inhibitor of ULK1 and ULK2 (ic50 of 2.9 and 1.1 nM, respectively).

 

Brand: BCM

 

Target: Autophagy

 

Signaling Pathways: Autophagy

 

In Vitro: MRT68921 disrupts the maturation of autophagosomes by inhibiting ULK1-specific inhibition, thus blocking the autophagy tide.

 

Solubility: Soluble in DMSO (warmed with 50ºC water bath). Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: CN1CCC2=C(C1)C=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4CCC4)C5CC5.Cl  

 

InChIKey: SCEOGAWLKSVXHH-UHFFFAOYSA-N  

 

InChI: InChI=1S/C25H34N6O.ClH/c1-31-13-10-19-14-21(9-8-20(19)16-31)29-25-28-15-22(17-6-7-17)23(30-25)26-11-3-12-27-24(32)18-4-2-5-18;/h8-9,14-15,17-18H,2-7,10-13,16H2,1H3,(H,27,32)(H2,26,28,29,30);1H

 

Attribute
[Chem Name]	N-[3-[[5-cyclopropyl-2-[(2-methyl-3,4-dihydro-1H-isoquinolin-6-yl)amino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide;hydrochloride
[Synonym]	MRT68921 HCl; MRT68921; MRT68921 hydrochloride
[CAS No.]	2070014-87-6
[MDL No.]	MFCD30187515
[Formula]	C25H35ClN6O
[Molecular]	471.05
[Form]	Solid powder
[Storage]	Under inert gas (nitrogen or Argon) at 2-8°C

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