RG14620 (Tyrphostin RG14620) is an EGFR inhibitor that directly inhibits ABCG2/BCRP delivery.

 

Brand: BCM

 

Target: EGFR; HER

 

Signaling Pathways: Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors

 

Melting Point: 150-151℃

 

Boiling Point: 418.2±45.0 °C(Predicted)

 

pKa: 2.97±0.12(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Sensitivity: Light Sensitive

 

Isomeric SMILES: C1=CC(=CN=C1)/C(=C\C2=CC(=CC(=C2)Cl)Cl)/C#N  

 

InChIKey: TYXIVBJQPBWBHO-QCDXTXTGSA-N  

 

InChI: InChI=1S/C14H8Cl2N2/c15-13-5-10(6-14(16)7-13)4-12(8-17)11-2-1-3-18-9-11/h1-7,9H/b12-4-

 

Attribute
[Chem Name]	(E)-3-(3,5-dichlorophenyl)-2-pyridin-3-ylprop-2-enenitrile
[Synonym]	RG14620; Tyrphostin RG14620; RG-14620
[CAS No.]	136831-49-7
[MDL No.]	MFCD00236445
[Formula]	C14H8Cl2N2
[Molecular]	275.13
[Form]	White to Light yellow solid
[Storage]	Stored at −20°C

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