UPGL00004 is a potent glutaminase C (GAC) inhibitor with IC50 of 29 nM, which is more selective to GAC than GLS2.

 

Brand: BCM

 

Target: Glutaminase C:（kd）27 nM, Glutaminase C:29 nM, Glutaminase C():29 nM, Glutaminase C:27 nM（kd）

 

Signaling Pathways: Others; Proteases/Proteasome

 

In Vitro: UPGL00004 inhibits MDA-MB-231, HS578T, and TSE cells (IC50s: 70, 129, and 262 nM, respectively).

 

pKa: 9.23±0.50(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: C1CN(CCC1NC2=NN=C(S2)NC(=O)CC3=CC=CC=C3)C4=NN=C(S4)NC(=O)CC5=CC=CC=C5  

 

InChIKey: MRYCNTHLPRENBA-UHFFFAOYSA-N  

 

InChI: InChI=1S/C25H26N8O2S2/c34-20(15-17-7-3-1-4-8-17)27-23-30-29-22(36-23)26-19-11-13-33(14-12-19)25-32-31-24(37-25)28-21(35)16-18-9-5-2-6-10-18/h1-10,19H,11-16H2,(H,26,29)(H,27,30,34)(H,28,31,35)

 

Attribute
[Chem Name]	2-phenyl-N-[5-[[1-[5-[(2-phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]piperidin-4-yl]amino]-1,3,4-thiadiazol-2-yl]acetamide
[Synonym]	UPGL00004
[CAS No.]	1890169-95-5
[Formula]	C25H26N8O2S2
[Molecular]	534.66
[Form]	Solid powder
[Storage]	Stored at -20°C

Goods Tag