WM-3835 is a novel, highly specific small molecule Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) inhibitor, which can effectively inhibit the proliferation and migration of OS cells and lead to apoptosis activation.

 

Brand: BCM

 

Target: Apoptosis; Histone Methyltransferase; Histone Acetyltransferase

 

Signaling Pathways: Apoptosis; Chromatin/Epigenetic

 

In Vitro: WM-3835, a novel and high-specific small molecule HBO1 inhibitor, was able to potently suppressed OS cell proliferation and migration, and led to apoptosis activation.

 

pKa: 7.26±0.25(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

GHS: GHS05

 

Isomeric SMILES: CC1=CC(=CC(=C1F)C(=O)NNS(=O)(=O)C2=CC=CC(=C2)O)C3=CC=CC=C3  

 

InChIKey: KVJFJJXCBRSCDY-UHFFFAOYSA-N  

 

InChI: InChI=1S/C20H17FN2O4S/c1-13-10-15(14-6-3-2-4-7-14)11-18(19(13)21)20(25)22-23-28(26,27)17-9-5-8-16(24)12-17/h2-12,23-24H,1H3,(H,22,25)

 

Attribute
[Chem Name]	2-fluoro-N'-(3-hydroxyphenyl)sulfonyl-3-methyl-5-phenylbenzohydrazide
[Synonym]	WM-3835; WM3835
[CAS No.]	2229025-70-9
[Formula]	C20H17FN2O4S
[Molecular]	400.42
[Form]	Solid powder
[Storage]	Keep in dark place. Sealed in dry, 2-8°C

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