Oltipraz is a potent Nrf2 activator and also a potent phase II detoxicating enzyme inducer, significantly acting on glutathione-S-transferase (GST). Phase 3.

 

Brand: BCM

 

Target: HIF/HIF Prolyl-Hydroxylase; HIV Protease; Reverse Transcriptase; Nrf2; HIF

 

Signaling Pathways: Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology; Proteases/Proteasome

 

In Vitro: Oltipraz, as a chemical protectant, induces phase II detoxification enzyme activity in an NrF2-dependent manner. [1] In human HT29 colon cancer cells, oltipraz inhibits the induction of HIF-1α by insulin, hypoxia or CoCl2, significantly accelerating the degradation of HIF-1α protein.

Melting Point: 165-166°C

 

Boiling Point: 408.1±55.0 °C(Predicted)

 

pKa: 0.18±0.10(Predicted)

 

Solubility: Soluble in DMSO (warmed with 50ºC water bath). Insoluble in Water; insoluble in Ethanol.

 

Sensitivity: Light Sensitive

 

GHS: GHS07

 

Isomeric SMILES: CC1=C(SSC1=S)C2=NC=CN=C2  

 

InChIKey: CKNAQFVBEHDJQV-UHFFFAOYSA-N  

 

InChI: InChI=1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3

 

Attribute
[Chem Name]	4-methyl-5-pyrazin-2-yldithiole-3-thione
[Synonym]	Oltipraz
[CAS No.]	64224-21-1
[EINECS]	264-736-6
[MDL No.]	MFCD00868499
[Formula]	C8H6N2S3
[Molecular]	226.34
[Form]	Red solid powder
[Storage]	Sealed in dry, 2-8°C

Goods Tag