TH1760 (Compound 18) is a first-in-class, potent, selective and cytoactive NUDT15 (MTH2) inhibitor with an IC50 value of 25 nM.

 

Brand: BCM

 

pKa: 8.55±0.70(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Ethanol; insoluble in Water.

 

Isomeric SMILES: C1CN(CCN1C(=O)C2=CC3=C(C=C2)NC=C3)S(=O)(=O)C4=CC5=C(C=C4)NC(=O)O5  

 

InChIKey: HNCVDRFFJZJQRW-UHFFFAOYSA-N  

 

InChI: InChI=1S/C20H18N4O5S/c25-19(14-1-3-16-13(11-14)5-6-21-16)23-7-9-24(10-8-23)30(27,28)15-2-4-17-18(12-15)29-20(26)22-17/h1-6,11-12,21H,7-10H2,(H,22,26)

 

Attribute
[Chem Name]	6-[4-(1H-indole-5-carbonyl)piperazin-1-yl]sulfonyl-3H-1,3-benzoxazol-2-one
[Synonym]	TH1760; Compound 18
[CAS No.]	2567914-01-4
[Formula]	C20H18N4O5S
[Molecular]	426.45
[Form]	Off-white solid
[Storage]	Stored at -20°C

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