UBCS039, the first synthetic SIRT6 activator with an EC50 of 38 μM, induces time-dependent activation of autophagy in a variety of human tumor cell lines.

 

Brand: BCM

 

Target: Sirtuin; Autophagy

 

Signaling Pathways: Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair

 

In Vitro: UBCS039 induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells.UBCS039 leads to autophagosome accumulation and induces autophagic flux in human cancer cells.UBCS039 also induces autophagy-associated cell death.

 

Boiling Point: 453.9±45.0 °C(Predicted)

 

pKa: 4.66±0.12(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: C1=CC=C2C(=C1)NC(C3=CC=CN32)C4=CN=CC=C4  

 

InChIKey: BSOBGTYXYGHUTD-UHFFFAOYSA-N  

 

InChI: InChI=1S/C16H13N3/c1-2-7-14-13(6-1)18-16(12-5-3-9-17-11-12)15-8-4-10-19(14)15/h1-11,16,18H 

 

Attribute
[Chem Name]	4-pyridin-3-yl-4,5-dihydropyrrolo[1,2-a]quinoxaline
[Synonym]	UBCS039; UBCS-039
[CAS No.]	358721-70-7
[MDL No.]	MFCD00206184
[Formula]	C16H13N3
[Molecular]	247.29
[Form]	Solid powder
[Storage]	Sealed in dry, 2-8°C

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