Thalidomide acts as a sedative, immunomodulator and is also used in research to treat the symptoms of many cancers. Thalidomide inhibits cereblon (CRBN), which is part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1.

 

Brand: BCM

 

Target: Apoptosis; TNF; Autophagy; Ligand for E3 Ligase; Molecular Glues

 

Signaling Pathways: Apoptosis; Autophagy; PROTAC

 

In Vivo: Thalidomide (200 mg/kg) resulted in inhibition of the vascularized corneal area in rabbits, with inhibition rates ranging from 30% to 51% in three experiments, with a median inhibition rate of 36%.

 

Melting Point: 269-271°C

 

Boiling Point: 401.48°C (rough estimate)

 

pKa: 10.70±0.40(Predicted)

 

λmax: 300nm(lit.)

 

Solubility: Soluble in DMSO. Insoluble in Ethanol; insoluble in Water.

 

GHS: GHS06, GHS08

 

Isomeric SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O  

 

InChIKey: UEJJHQNACJXSKW-UHFFFAOYSA-N  

 

InChI: InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)

 

Attribute
[Chem Name]	2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
[Synonym]	Thalidomide; K17
[CAS No.]	50-35-1
[EINECS]	200-031-1
[MDL No.]	MFCD00153873
[Formula]	C13H10N2O4
[Molecular]	258.23
[Form]	White solid
[Storage]	Keep in dark place. Sealed in dry. Room Temperature

Goods Tag