Wdr5-in-6 is a WDR5 inhibitor that targets the WBM site. WDR5-IN-6 inhibits the proliferation of neuroblastoma cell lines and has strong antitumor activity. Wdr5-in-6 is highly synergistic with the WDR5 inhibitor OICR-9429 (HY-16993), which targets the WIN site. WDR5-IN-6 can be used in the study of neuroblastoma.

 

Brand: BCM

 

Target: WDR5

 

In Vitro: WDR5-IN-6 (compound 19) inhibited the proliferation of IMR32 and LAN5 cells with EC50 values of 12.34 and 14.89 μM, respectively, and had moderate inhibitory effect on SK-N-AS cells, but had no effect on HEK293T cells at 20 μM.

 

Boiling Point: 525.7±60.0 °C(Predicted)

 

pKa: -0.28±0.10(Predicted)

 

Isomeric SMILES: C1=CC=C2C(=C1)N=CN2S(=O)(=O)C3=C(C=CC(=C3)Cl)Cl  

 

InChIKey: PXUHMEZESKEPKJ-UHFFFAOYSA-N  

 

InChI: InChI=1S/C13H8Cl2N2O2S/c14-9-5-6-10(15)13(7-9)20(18,19)17-8-16-11-3-1-2-4-12(11)17/h1-8H

 

Attribute
[Chem Name]	1-(2,5-dichlorophenyl)sulfonylbenzimidazole
[Synonym]	WDR5IN 6 ; WDR5-IN 6 ; WDR5 IN-6; WDR5IN6
[CAS No.]	326901-92-2
[MDL No.]	MFCD00828171
[Formula]	C13H8Cl2N2O2S
[Molecular]	327.19
[Form]	White to off-white solid
[Storage]	Sealed in dry. Stored at -20°C

Goods Tag