NX-2127 is a unique and potent BTK inhibitor that blocks its function by catalyzing ubiquitination and proteasome degradation of BTK rather than by direct binding. NX-2127 can stimulate T cell activation and increase IL-2 production in primary human T cells.

 

Brand: BCM

 

Target: Btk

 

In Vitro: NX-2127 inhibited the proliferation of BTK-C481S mutant TMD8 cells with EC50 values <30 nM. NX-2127 increases IL-2 production in primary human T cells.

 

Boiling Point: 949.0±65.0 °C(Predicted)

 

pKa: 10.83±0.40(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: C1CCN(CC1)C2=CN=C(C(=N2)NC3=CC=C(C=C3)C4CCN(CC4)C[C@@H]5CCN(C5)C6=CC7=C(C=C6)C(=O)N(C7=O)C8CCC(=O)NC8=O)C(=O)N  

 

InChIKey: XLWJWCMQMBVNSG-ACXKHFGCSA-N  

 

InChI: InChI=1S/C39H45N9O5/c40-35(50)34-36(43-32(21-41-34)46-15-2-1-3-16-46)42-27-6-4-25(5-7-27)26-13-17-45(18-14-26)22-24-12-19-47(23-24)28-8-9-29-30(20-28)39(53)48(38(29)52)31-10-11-33(49)44-37(31)51/h4-9,20-21,24,26,31H,1-3,10-19,22-23H2,(H2,40,50)(H,42,43)(H,44,49,51)/t24-,31?/m0/s1

 

Attribute
[Chem Name]	3-[4-[1-[[(3S)-1-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]pyrrolidin-3-yl]methyl]piperidin-4-yl]anilino]-5-piperidin-1-ylpyrazine-2-carboxamide
[Synonym]	NX-2127
[CAS No.]	2416131-46-7
[Formula]	C39H45N9O5
[Molecular]	719.83
[Form]	Solid powder
[Storage]	Sealed in dry. Stored at -20°C

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