MF-766 is a highly effective and orally active selective EP4 antagonist with a Ki of 0.23 nM. It appears as a complete antagonist in functional tests with an IC50 of 1.4 nM (which becomes 1.8 nM in the presence of 10% HS). It has value for cancer and inflammatory disease research.

 

Brand: BCM

 

Target: Prostaglandin Receptor

 

Signaling Pathways: GPCR/G Protein; Immunology/Inflammation

 

In Vitro: MF-766 (0.01-10 μM; Pre-treated for 1 hour, then stimulated with 50 ng/mL IL-2; With and without 0.33μM PGE2; 18 h) reversed PGE2-inhibited IFN-γ secretion in human NK cells. In addition, NK cell activity was not affected by MF-766.

 

Boiling Point: 711.4±60.0 °C at 760 mmHg

 

Flashing Point: 384.1±32.9 °C

 

pKa: 4.35±0.10(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: C1CC1(C2=CC=C(C=C2)C(=O)O)NC(=O)C3=CC=CC4=C3N(C=C4)CC5=CC=C(C=C5)C(F)(F)F  

 

InChIKey: BWXAZFCPGFKANL-UHFFFAOYSA-N  

 

InChI: InChI=1S/C27H21F3N2O3/c28-27(29,30)21-8-4-17(5-9-21)16-32-15-12-18-2-1-3-22(23(18)32)24(33)31-26(13-14-26)20-10-6-19(7-11-20)25(34)35/h1-12,15H,13-14,16H2,(H,31,33)(H,34,35) 

 

Attribute
[Chem Name]	4-[1-[[1-[[4-(trifluoromethyl)phenyl]methyl]indole-7-carbonyl]amino]cyclopropyl]benzoic acid
[Synonym]	MF-766; MF766
[CAS No.]	1050656-06-8
[Formula]	C27H21F3N2O3
[Molecular]	478.46
[Form]	Solid powder
[Storage]	Sealed in dry. Stored at -20°C

Goods Tag