Eeyarestatin I is a potent inhibitor of endoplasmic reticulum-associated protein degradation (ERAD). Eeyarestatin I also inhibits the Sec61 translocon.

 

Brand: BCM

 

Target: P97:> 30 μM, UbG76V-GFP:3.7 μM

 

Signaling Pathways: Apoptosis

 

pKa: 9.13±0.40(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CC1(C(N(C(=O)N1CC(=O)NN=CC=CC2=CC=C(O2)[N+](=O)[O-])C3=CC=C(C=C3)Cl)N(C(=O)NC4=CC=C(C=C4)Cl)O)C  

 

InChIKey: JTUXTPWYZXWOIB-UHFFFAOYSA-N  

 

InChI: InChI=1S/C27H25Cl2N7O7/c1-27(2)24(35(40)25(38)31-19-9-5-17(28)6-10-19)34(20-11-7-18(29)8-12-20)26(39)33(27)16-22(37)32-30-15-3-4-21-13-14-23(43-21)36(41)42/h3-15,24,40H,16H2,1-2H3,(H,31,38)(H,32,37)

 

Attribute
[Chem Name]	2-[3-(4-chlorophenyl)-4-[(4-chlorophenyl)carbamoyl-hydroxyamino]-5,5-dimethyl-2-oxoimidazolidin-1-yl]-N-[3-(5-nitrofuran-2-yl)prop-2-enylideneamino]acetamide
[Synonym]	Eeyarestatin I
[CAS No.]	412960-54-4
[MDL No.]	MFCD00319108
[Formula]	C27H25Cl2N7O7
[Molecular]	630.44
[Form]	Yellow to orange solid powder
[Storage]	-20°C, sealed storage, away from moisture

Goods Tag