β-Amyloid (25-35), sequence GSNKGAIIGLM, is A highly toxic synthetic derivative of amyloid β-peptide (Aβ-peptide) that forms fibrous aggregates. Beta-amyloid protein (25-35) is involved in the pathogenesis of Alzheimer's disease.

 

Brand: BCM

 

Target: Beta Amyloid

 

Signaling Pathways: Neuroscience

 

In Vitro: The amino acid sequence of the Aβ(25-35) peptide is NH2-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-COOH, where the first Gly represents amino acid 25 and the last Met represents amino acid 35. Amyloid beta-peptide (25-35) was also studied for the first time in a gel state. Comparative studies were also conducted using vibration absorption and ECD. The conformational preferences of Aβ(25-35) peptide films were also investigated using vibration absorption and VCD spectroscopy. Amyloid beta peptide (25-35) induces apoptotic effects on isolated brain mitochondria and the REDOX state of methionine-35, which plays a key role in inducing programmed cell death pathways and toxic events.

 

Boiling Point: 1517.336ºC at 760 mmHg

 

Flashing Point: 871.453ºC

 

pKa: 3.24±0.10(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)CN  

 

InChIKey: WIHBNMPFWRHGDF-SLVFWPMISA-N  

 

InChI: InChI=1S/C45H81N13O14S/c1-9-24(5)36(43(69)50-21-35(63)52-29(17-23(3)4)40(66)55-28(45(71)72)14-16-73-8)58-44(70)37(25(6)10-2)57-38(64)26(7)51-34(62)20-49-39(65)27(13-11-12-15-46)54-41(67)30(18-32(48)60)56-42(68)31(22-59)53-33(61)19-47/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,69)(H,51,62)(H,52,63)(H,53,61)(H,54,67)(H,55,66)(H,56,68)(H,57,64)(H,58,70)(H,71,72)/t24-,25-,26-,27-,28-,29-,30-,31-,36-,37-/m0/s1

 

Attribute
[Chem Name]	(2S)-2-[[(2S)-2-[[2-[[(2S,3S)-2-[[(2S,3S)-2-[[(2S)-2-[[2-[[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]amino]acetyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoic acid
[Synonym]	β-Amyloid (25-35); Amyloid beta-peptide (25-35); Aβ25-35; β-Amyloid peptide (25-35)
[CAS No.]	131602-53-4
[MDL No.]	MFCD00133076
[Formula]	C45H81N13O14S
[Molecular]	1060.27
[Form]	White Lyophilized Powder
[Storage]	Keep in dark place. Inert atmosphere. Store in freezer, under -20°C

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