BD750 is an immunosuppressant and dual inhibitor of JAK3 and STAT5, which can inhibit JAK3/ STAT5-dependent T cell proliferation induced by IL-2, with IC50 values of 1.5 μM in mice and 1.1 μM in human T cell proliferation.

 

Brand: BCM

 

Target: JAK; STAT

 

Signaling Pathways: Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells

 

Boiling Point: 509.4±60.0 °C(Predicted)

 

pKa: 7.38±0.20(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

GHS: GHS06

Isomeric SMILES: C1CCC2=C(C1)C(=O)N(N2)C3=NC4=CC=CC=C4S3  

 

InChIKey: QWUHPPCZZXKXOQ-UHFFFAOYSA-N  

 

InChI: InChI=1S/C14H13N3OS/c18-13-9-5-1-2-6-10(9)16-17(13)14-15-11-7-3-4-8-12(11)19-14/h3-4,7-8,16H,1-2,5-6H2

 

Attribute
[Chem Name]	2-(1,3-benzothiazol-2-yl)-4,5,6,7-tetrahydro-1H-indazol-3-one
[Synonym]	BD750
[CAS No.]	892686-59-8
[MDL No.]	MFCD08132253
[Formula]	C14H13N3OS
[Molecular]	271.34
[Form]	White to light brown powder
[Storage]	Keep in dark place. Inert atmosphere. Room temperature

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