Ophiopogonin D (OJV-VI, Deacetylophiopogonin C) is a steroid glycoside isolated from the Chinese herbal medicine Ophiopogon. Ophiopogonin D can inhibit TGF-β1-mediated MDA-MB-231 cell metastasis by modulating the ITGB1/FAK/Src/AKT/β-catenin/MMP-9 signaling axis. Ophiopogonin D also reduced PM2.5-induced inflammation by inhibiting the AMPK/NF-κB pathway in mouse lung epithelial cells.

 

Brand: BCM

 

Target: PPAR; RAAS; NF-κB; Calcium Channel

 

Signaling Pathways: DNA Damage/DNA Repair; Endocrinology/Hormones; Membrane transporter/Ion channel; Metabolism; NF-κB

 

Melting Point: 263-265 °C

 

pKa: 13.01±0.70(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5([C@@H](C[C@@H](C6)O)O[C@H]7[C@@H]([C@H]([C@H]([C@H](O7)C)O)O[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O)O)C)C)C)OC1  

 

InChIKey: FHKHGNFKBPFJCB-LYLKFOBISA-N  

 

InChI: InChI=1S/C44H70O16/c1-18-9-12-44(54-16-18)19(2)30-28(60-44)15-26-24-8-7-22-13-23(45)14-29(43(22,6)25(24)10-11-42(26,30)5)57-41-38(59-40-36(52)34(50)31(47)20(3)55-40)37(32(48)21(4)56-41)58-39-35(51)33(49)27(46)17-53-39/h7,18-21,23-41,45-52H,8-17H2,1-6H3/t18-,19+,20+,21-,23-,24-,25+,26+,27-,28+,29-,30+,31+,32+,33+,34-,35-,36-,37+,38-,39+,40+,41+,42+,43+,44-/m1/s1

 

Attribute
[Chem Name]	(2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-5-hydroxy-2-[(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,14R,16R)-16-hydroxy-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-14-yl]oxy-6-methyl-4-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol
[Synonym]	OJV-VI; Ophiopogonin D; Deacetylophiopogonin C
[CAS No.]	945619-74-9
[MDL No.]	MFCD09970543
[Formula]	C44H70O16
[Molecular]	855.03
[Form]	A solid
[Storage]	Sealed in dry. Store in freezer, under -20°C

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