Calpeptin is a potent, cell-permeable calpain inhibitor against calsin I (porcine red blood cells), calsin II (porcine kidneys), papain, and calsin I (human platelets) with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM, respectively. Calpeptin reduces apoptosis and intracellular inflammatory changes in muscle cells.

 

Brand: BCM

 

Target: Cysteine Protease; Apoptosis; Proteasome

 

Signaling Pathways: Apoptosis; Proteases/Proteasome; Ubiquitination

 

In Vivo: Calpeptin inhibits 20K phosphorylation in a dose-dependent manner in thrombin, iomycin, or collagen-stimulated platelets. In differentiated PC12 cells, Calpeptin promotes neurite elongation by inhibiting calpsin activity. In rat retinal ganglion cells, Calpeptin reduced apoptosis and maintained normal whole-cell membrane potential, thereby providing functional neuroprotection.

 

Melting Point: 60-75 °C

 

Boiling Point: 494.07°C (rough estimate)

 

pKa: 11.14±0.46(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: CCCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1  

 

InChIKey: PGGUOGKHUUUWAF-ROUUACIJSA-N  

 

InChI: InChI=1S/C20H30N2O4/c1-4-5-11-17(13-23)21-19(24)18(12-15(2)3)22-20(25)26-14-16-9-7-6-8-10-16/h6-10,13,15,17-18H,4-5,11-12,14H2,1-3H3,(H,21,24)(H,22,25)/t17-,18-/m0/s1

 

Attribute
[Chem Name]	benzyl N-[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxohexan-2-yl]amino]pentan-2-yl]carbamate
[Synonym]	Calpeptin
[CAS No.]	117591-20-5
[MDL No.]	MFCD00155623
[Formula]	C20H30N2O4
[Molecular]	362.46
[Form]	White to off-white solid
[Storage]	Inert atmosphere. Store in freezer, under -20°C

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