4μ8C (IRE1 Inhibitor III) is a highly selective IRE1 Rnase inhibitor with an IC50 of 76 nM.

 

Brand: BCM

 

Target: IRE1

 

Signaling Pathways: Cell Cycle/Checkpoint

 

In Vitro: 4μ8C blocks substrate(RIDD) access to the active site of IRE1 and selectively inactivates both Xbp1 splicing and IRE1-mediated mRNA degradation. IRE1 inhibition subsequently induces ER stress without measureable acute toxicity.  4μ8C, as an IRE1 inhibitor, blocks IL-4, IL-5, and IL-13 production from CD4+ T cells.

 

Melting Point: 189-190℃ (ethanol)

 

Boiling Point: 398.3±42.0 °C(Predicted)

 

pKa: 6.22±0.20(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07,GHS08

 

Isomeric SMILES: CC1=CC(=O)OC2=C1C=CC(=C2C=O)O  

 

InChIKey: RTHHSXOVIJWFQP-UHFFFAOYSA-N  

 

InChI: InChI=1S/C11H8O4/c1-6-4-10(14)15-11-7(6)2-3-9(13)8(11)5-12/h2-5,13H,1H3

 

Attribute
[Chem Name]	7-hydroxy-4-methyl-2-oxochromene-8-carbaldehyde
[Synonym]	4μ8C; IRE1 Inhibitor III
[CAS No.]	14003-96-4
[MDL No.]	MFCD12027255
[Formula]	C11H8O4
[Molecular]	204.18
[Form]	Off-white to Yellow Powder
[Storage]	Inert atmosphere. Store in freezer, under -20°C

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