O-304 (O-304X) is an orally active panactivator of AMPK activated protein kinase (AMPK). O-304 (O-304X) has great potential as a novel agent for the treatment of type 2 diabetes (T2D) and related cardiovascular complications. 

 

Brand: BCM

 

Target: AMPK

 

Signaling Pathways: Chromatin/Epigenetic; PI3K/Akt/mTOR signaling

 

In Vivo: In vivo, O-304 (100 mg/kg) prevents high-fat diet-induced increases in fasted glucose and plasma insulin levels and development of insulin resistance, as well as increases calf muscle pAMPK levels in mice.

 

pKa: 7.81±0.20(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: C1=CC(=CC=C1CN2C(=O)N=C(S2)NC(=O)C3=CC=C(C=C3)Cl)Cl  

 

InChIKey: WEDWLYRQKUTOAX-UHFFFAOYSA-N  

 

InChI: InChI=1S/C16H11Cl2N3O2S/c17-12-5-1-10(2-6-12)9-21-16(23)20-15(24-21)19-14(22)11-3-7-13(18)8-4-11/h1-8H,9H2,(H,19,20,22,23)

 

Attribute
[Chem Name]	4-chloro-N-[2-[(4-chlorophenyl)methyl]-3-oxo-1,2,4-thiadiazol-5-yl]benzamide
[Synonym]	O-304; O-304X
[CAS No.]	1261289-04-6
[MDL No.]	MFCD31657425
[Formula]	C16H11Cl2N3O2S
[Molecular]	380.25
[Form]	A crystalline solid
[Storage]	Inert atmosphere. Room Temperature

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