PLpro inhibitor (compound 6) is a potent inhibitor of papain-like protease (PLpro)/deubiquitinase (DUBs) with IC50 of 2.6 μM and EC50 of 13.1 μM. Can prevent SARS virus replication.

 

Brand: BCM

 

Target: SARS-CoV

 

Signaling Pathways: Microbiology/Virology

 

Boiling Point: 584.7±50.0 °C(Predicted)

 

pKa: 14.13±0.46(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CC1=C(C=C(C=C1)NC(=O)C)C(=O)N[C@H](C)C2=CC=CC3=CC=CC=C32  

 

InChIKey: KGPYBLOBHQLIET-OAHLLOKOSA-N  

 

InChI: InChI=1S/C22H22N2O2/c1-14-11-12-18(24-16(3)25)13-21(14)22(26)23-15(2)19-10-6-8-17-7-4-5-9-20(17)19/h4-13,15H,1-3H3,(H,23,26)(H,24,25)/t15-/m1/s1

 

Attribute
[Chem Name]	5-acetamido-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide
[Synonym]	PLpro inhibitor
[CAS No.]	1093070-14-4
[MDL No.]	MFCD12547684
[Formula]	C22H22N2O2
[Molecular]	346.42
[Form]	Powder
[Storage]	Sealed in dry. Room Temperature

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