p38-α MAPK-IN-1 is an inhibitor of p38-α with an IC50 value of 2300 nM in EFC replacement tests and 5500 nM in HTRF tests.

 

Brand: BCM

 

Target: Autophagy; p38 MAPK

 

Signaling Pathways: Autophagy; MAPK

 

In Vitro: p38-α MAPK-IN-1 is a MAPK14 (p38-α)?inhibitor(IC50 of 2300 nM, in EFC displacement assay, and 5500 nM in HTRF assay)

 

Boiling Point: 566.2±50.0 °C(Predicted)

 

pKa: 13.76±0.70(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C=C3)OCCN4CCOCC4  

 

InChIKey: FRZNJFWQVYAVCE-UHFFFAOYSA-N  

 

InChI: InChI=1S/C27H35N5O3/c1-20-5-9-22(10-6-20)32-25(19-24(30-32)27(2,3)4)29-26(33)28-21-7-11-23(12-8-21)35-18-15-31-13-16-34-17-14-31/h5-12,19H,13-18H2,1-4H3,(H2,28,29,33)

 

Attribute
[Chem Name]	1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)phenyl]urea
[Synonym]	p38-α MAPK-IN-1
[CAS No.]	443913-15-3
[MDL No.]	MFCD30533549
[Formula]	C27H35N5O3
[Molecular]	477.6
[Form]	Solid Powder
[Storage]	Store at -20°C

Goods Tag