AOH1996 is an orally active small molecule PCNA inhibitor with potential antitumor activity. It enhances the interaction between PCNA and RPB1, the largest subunit of RNA polymerase II.

 

Brand: BCM

 

Target: DNA/RNA Synthesis; Apoptosis

 

Signaling Pathways: Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair

 

Boiling Point: 703.9±50.0 °C(Predicted)

 

pKa: 12.87±0.70(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: COC1=CC(=CC=C1)OC2=CC=CC=C2NC(=O)CNC(=O)C3=CC=CC4=CC=CC=C43  

 

InChIKey: HDMONPHKMIZXDH-UHFFFAOYSA-N  

 

InChI: InChI=1S/C26H22N2O4/c1-31-19-10-7-11-20(16-19)32-24-15-5-4-14-23(24)28-25(29)17-27-26(30)22-13-6-9-18-8-2-3-12-21(18)22/h2-16H,17H2,1H3,(H,27,30)(H,28,29)

 

Attribute
[Chem Name]	N-[2-[2-(3-methoxyphenoxy)anilino]-2-oxoethyl]naphthalene-1-carboxamide
[Synonym]	AOH1996; AOH-1996; AOH 1996
[CAS No.]	2089314-64-5
[Formula]	C26H22N2O4
[Molecular]	426.46
[Form]	Powder
[Storage]	Sealed in dry. Stored at -20°C.

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