Danicamtiv (MYK-491, SAR 440181) is a novel cardiac myosin activator that enhances cardiomyocyte contraction.

 

Brand: BCM

 

Target: Myosin

 

Signaling Pathways: Cytoskeletal Signaling

 

Boiling Point: 699.1±55.0 °C(Predicted)

 

pKa: 13.32±0.40(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: C[C@@](C1CCN(CC1)C(=O)NC2=NOC=C2)(F)S(=O)(=O)C3=CN(N=C3C(F)F)C  

 

InChIKey: NREKKBAMVWQRES-MRXNPFEDSA-N  

 

InChI: InChI=1S/C16H20F3N5O4S/c1-16(19,29(26,27)11-9-23(2)21-13(11)14(17)18)10-3-6-24(7-4-10)15(25)20-12-5-8-28-22-12/h5,8-10,14H,3-4,6-7H2,1-2H3,(H,20,22,25)/t16-/m1/s1

 

Attribute
[Chem Name]	4-[(1R)-1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonyl-1-fluoroethyl]-N-(1,2-oxazol-3-yl)piperidine-1-carboxamide
[Synonym]	Danicamtiv; MYK-491; SAR 440181
[CAS No.]	1970972-74-7
[Formula]	C16H20F3N5O4S
[Molecular]	435.42
[Form]	Solid Powder
[Storage]	Sealed in dry. Stored at -20°C

Goods Tag