CZC-25146 is a potent and selective LRRK2 inhibitor with an IC50 of 4.76 nM for human wild type LRRK2 and 6.87 nM for G2019S LRRK2.

 

Brand: BCM

 

Target: LRRK2

 

Signaling Pathways: Autophagy

 

Boiling Point: 697.4±65.0 °C(Predicted)

 

pKa: 8.48±0.10(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)F  

 

InChIKey: XXHHOTZUJIXPJX-UHFFFAOYSA-N  

 

InChI: InChI=1S/C22H25FN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27)

 

Attribute
[Chem Name]	N-[2-[[5-fluoro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl]methanesulfonamide
[Synonym]	CZC-25146
[CAS No.]	1191911-26-8
[MDL No.]	MFCD28160475
[Formula]	C22H25FN6O4S
[Molecular]	488.54
[Form]	Solid Powder
[Storage]	Keep in dark place. Inert atmosphere. Room temperature

Goods Tag